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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Amanda Black

Programs

OnDemand

Roles

Affinity Group Leader, OnDemand

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Expertise

Chad Julius

South Dakota State University

Programs

Campus Champions, Great Plains

Roles

mentor, research computing facilitator

Expertise

Maureen Dougherty

Ecosystem for Research Networking

Programs

OnDemand

Roles

representative, Affinity Group Leader

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Expertise

People with Interest

Dr. Nabeel Alzahrani

California State University-San Bernardino

Programs

Campus Champions, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, ci systems engineer, CCMNet

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Interests

Michael Weiner

Georgia Institute of Technology

Programs

Campus Champions, CCMNet

Roles

CampusChampionsAdmin, research computing facilitator, Affinity Group Leader, CCMNet

Michael Weiner

Interests

Russell Hofmann

Internet2

Programs

ACCESS CSSN, CCMNet

Roles

mentor, cssn, CCMNet

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Interests