Skip to main content

optimization

Affinity Groups

Logo Name Description Tags Join
Structural Biology OOD Apps This group is for researchers and support staff using structural biology tools like RELION, cryoSPARC, PHENIX, IMOD, and others through Open OnDemand. Whether you're optimizing workflows,… Login to join

Topics from Ask.CI

Loading topics from Ask.CI ...

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Andrew Monaghan

University of Colorado, Boulder

Programs

ACCESS CSSN

Roles

mentor

Photo of Andy Monaghan

Expertise

Stanley Nwoji

Harrisburg University of Science and Technology

Programs

CAREERS

Roles

researcher/educator

Stanley Nwoji, Ph.D.

Expertise

c
+38 more tags

Xiaoge Wang

Michigan State University

Programs

Campus Champions

Roles

research computing facilitator

Placeholder headshot

Expertise

c
+55 more tags

People with Interest

Andrew Rigg

Programs

CAREERS

Placeholder headshot

Interests

c
+28 more tags

Matt Ferguson

Boise State University

Programs

At-Large

Roles

researcher/educator, cssn

picture of Matt Ferguson

Interests

Liwen Shih

University of Houston-Clear Lake

Programs

Campus Champions, ACCESS CSSN, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, cssn, CCMNet

Placeholder headshot

Interests